Derived from the hop cones (Humulus lupulus) that give beer its bitterness, Xanthohumol  is now recognized as one of nature’s most versatile bioactive flavonoids. With over 300 preclinical studies validating its polypharmacological effects, Nanjing Spring & Autumn Biological Engineering Co., Ltd.’s 98% High-Purity Xanthohumol (CAS 6754-58-1) is unlocking next-generation solutions for metabolic syndrome, healthy aging, and chronic inflammation.

1. The Purity Imperative: Why ≥98% Xanthohumol Matters

Crude hops extracts contain <10% XN alongside humulones/lupulones that dilute efficacy. Our pharmaceutical-grade XN delivers:

• Uncompromised Bioactivity:
  Low-purity XN shows 5.8× reduced Nrf2 activation (Free Radic. Biol. Med., 2021)

• Taste Masking:
  Eliminates bitter isohumulones for palatable functional foods

• Batch Consistency:
  HPLC-verified purity (98–99.5%), heavy metals <0.5 ppm

2. Metabolic Master Regulator: Combating Diabetes & Obesity

A. Insulin Sensitivity Boost

• ↑ AMPK/PI3K signaling → 34% higher glucose uptake in skeletal muscle (Mol. Nutr. Food Res., 2022)

• ↓ Advanced Glycation End Products (AGEs) by 51% → Prevents diabetic complications

B. Lipid Homeostasis

• Dual inhibition of SREBP-1c (fat synthesis) + activation of PPARα (fat burning)

• Reduces liver triglycerides by 42% in NAFLD models (J. Nutr. Biochem., 2020)

C. Anti-Obesity Effects

• Suppresses adipogenesis via Wnt/β-catenin pathway

• Increases thermogenesis by 27% (browning of white fat)

3. Longevity & Cellular Defense: Beyond Antioxidants

A. Nrf2-Keap1 Pathway Activation

• Upregulates glutathione synthesis (↑ 300% GST activity)

• Crosses blood-brain barrier → Neuroprotection against Aβ oligomers

B. Senescence & Telomere Defense

• ↓ p16^INK4a expression (key senescence marker) by 61%

• Maintains telomere length via TERT activation (Aging Cell, 2023)

C. DNA Guardian

• Inhibits topoisomerase I/II errors → Antimutagenic in Ames test

• Repairs UV-induced thymine dimers

4. Broad-Spectrum Anti-Inflammatory & Antiviral Actions

A. Cytokine Storm Control

• Blocks NF-κB translocation → ↓ TNF-α, IL-6 (IC₅₀ = 1.8 μM)

• Inactivates NLRP3 inflammasome → 2.3× lower IL-1β in sepsis models

B. Viral Entry Inhibition

• Disrupts spike protein-ACE2 binding (molecular docking score: −9.2 kcal/mol)

• Suppresses 3CL^pro protease in coronaviruses (Phytother. Res., 2021)

5. Innovative Applications: From Nutraceuticals to Functional Foods

A. Synergistic Formulations

• Metabolic Health: XN + Berberine → 89% greater AMPK activation

• Liver Protection: XN + Silymarin → ↓ ALT/AST by 67%

• Longevity Drinks: XN + Resveratrol → ↑ SIRT1 activity 4.1×

B. Stability Solutions

• Cyclodextrin Encapsulation: Shelf-life extension to 36 months (25°C)

• Oil-Dispersible Powder: For gummies, bars, and emulsions

Why Nanjing Spring & Autumn’s Xanthohumol 98%?

As pioneers in hop phytochemistry, we guarantee:
? Vertically Sourced: EU Organic-certified hops (Hallertau region)
? Green Extraction: Supercritical CO₂ + preparative HPLC → Zero solvent residues
? Bioactivity Verification:

• Nrf2 activation EC₅₀: 0.75 μM

• ORAC value: 28,500 μmol TE/g
  ? Global Compliance: FDA GRAS, FSSC 22000, ISO 9001, Halal/Kosher

Conclusion: Harness Nature’s Multitarget Marvel

Premium Xanthohumol 98% (CAS 6754-58-1) transcends single-target approaches – simultaneously addressing metabolic dysfunction, oxidative stress, chronic inflammation, and cellular aging. With clinically relevant bioavailability and an exceptional safety profile, it empowers innovators across nutraceuticals, functional foods, and preventive healthcare.

→ Partner for Cutting-Edge Formulations
Contact Nanjing Spring & Autumn Biological Engineering for:

• Technical Dossiers (COA, MSDS, Stability Data)

• Custom Concentrates (10–50% for beverages)

• Clinical Trial Support