In today’s fast-paced world, maintaining muscle vitality and managing menopause naturally are critical yet challenging goals. 8-Prenylnaringenin (8-PN), a bioactive flavonoid derived from hops (Humulus lupulus), emerges as a scientifically backed solution for both. With unmatched purity and potency, Nanjing Spring & Autumn Biological Engineering Co., Ltd.’s 8-PN extract delivers targeted benefits for athletes, aging adults, and women navigating menopausal transitions. 1. What Is 8-Prenylnaringenin (8-PN) and Why Does Purity Matter? 8-PN belongs to the prenylated flavonoid family—compounds where a hydrophobic prenyl group enhances bioavailability and bioactivity. Unlike ordinary naringenin, the prenylation in 8-PN significantly boosts its cellular uptake and tissue accumulation, as demonstrated in intestinal  and muscle  cell studies. This structural advantage allows it to penetrate cell membranes more efficiently, leading to stronger biological effects at lower doses. High purity (≥98%) is non-negotiable for efficacy: Impurities can dilute benefits and introduce risks. Our extraction technology ensures pharmaceutical-grade 8-PN, free from contaminants like heavy metals or residual solvents, guaranteeing optimal potency and safety for human use. 2. Combat Muscle Loss and Boost Strength: The Science of 8-PN for Sarcopenia Age-related muscle loss (sarcopenia) begins as early as, with adults losing ~1% of muscle mass/year. Left unchecked, it escalates frailty, metabolic issues, and mortality risk. 8-PN addresses this crisis through multi-pathway actions: Superior Muscle Atrophy Prevention: In preclinical models, 8-PN outperformed non-prenylated naringenin in blocking muscle degradation pathways. Its enhanced cellular uptake enables direct modulation of muscle protein synthesis and breakdown, preserving lean mass. Synergy with Exercise: Resistance training alone can increase strength by 50% in 6 weeks. 8-PN amplifies this by reducing exercise-induced inflammation and accelerating recovery. Mitochondrial Optimization: By activating PGC-1α (a regulator of mitochondrial biogenesis), 8-PN improves muscle energy metabolism—critical for endurance and fatigue resistance. 3. Menopausal Relief: 8-PN as a Natural Estrogenic Regulator 8-PN is the most potent known phytoestrogen, binding strongly to estrogen receptors (ERα/ERβ). This makes it uniquely effective for menopause symptoms without synthetic hormones: Hot Flash & Night Sweat Reduction: Modulates hypothalamic thermoregulation via ER pathways. Bone Density Support: Activates osteoblast activity, reducing osteoporosis risk—a major concern for postmenopausal women. Unlike soy isoflavones, 8-PN’s prenyl group enables deeper tissue penetration, including bone and neural tissues. 4. Antioxidant and Anti-Inflammatory: The Foundational Benefits Beyond muscle and menopause, 8-PN provides systemic protection: Radical Scavenging: Neutralizes DPPH free radicals more effectively than non-prenylated flavonoids5, shielding cells from oxidative stress. NF-κB Pathway Inhibition: Suppresses pro-inflammatory genes (Il1b, Tnf, Il6), reducing chronic inflammation linked to arthritis, metabolic disorders, and aging. 5. Why Choose Nanjing Spring & Autumn Biological Engineering’s 8-PN? As a leader in bioactive natural products, we guarantee: Unrivaled Purity: ≥98% 8-PN verified via HPLC and NMR. Eco-Friendly Extraction: Patented green technology ensures sustainability. Custom Formulations: Available as powder, liquid, or softgel for functional foods, sports nutrition, and supplements. Conclusion: Embrace the Future of Natural Health with 8-PN High-purity 8-Prenylnaringenin bridges two urgent health needs: preserving muscle against aging and reclaiming comfort during menopause. Backed by rigorous science and advanced processing, Nanjing Spring & Autumn Biological Engineering empowers brands to deliver transformative products. → Partner with us to integrate premium 8-PN into your line. Contact sale05@cqherb.com for certificates, samples, and clinical references.