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High-Purity Angelicin (Isopsoralen) Natural Extract ≥98% | Research & Pharmaceutical Grade
Isopsoralen (Angelicin) is a high-purity angular furanocoumarin compound extracted from Psoralea corylifolia fruit.
With HPLC-confirmed purity ≥98%, this bioactive molecule serves as a critical standard in pharmaceutical research, dermatology, and natural product synthesis.
Product Name :
IsopsoralenCAS No. :
523-50-2Appearance :
White crystalline powderSpecification :
98%CAS: 523-50-2
Molecular Formula: C??H?O?
Molecular Weight: 186.16 g/mol
Appearance: White crystalline powder
Targeted Photochemotherapy & DNA Repair Modulator
≥98% Purity (HPLC-UV validated, λmax 246 nm)
Superior Photoactivation: 3.7× faster DNA binding vs. psoralen under UVA (320-400 nm)
Antifungal Specificity: Disrupts chitin synthase (IC??: 18 μM vs. Candida)
Dermatological Applications
Vitiligo Therapy: 0.05% cream + UVA achieves 90% repigmentation in 16 weeks
Psoriasis Control: Reduces IL-23 by 62% at 10 μM (PASI score ↓54%)
Oncological Mechanisms
DNA Crosslinking: Forms 4,5-monoadducts with thymidine (UVA-dependent)
Metastasis Blockade: Inhibits MMP-2 secretion by 79% at 25 μM
Antimicrobial Action
Antifungal: Targets β-(1,3)-glucan synthase (MIC 8 μg/mL vs. Aspergillus)
Antiviral: Inactivates HSV-1 by 99.9% at 50 μM under UVA
| Parameter | Detail |
|---|---|
| Purity | ≥98% (HPLC-DAD, C18, 246 nm) |
| Source | Psoralea corylifolia seeds |
| Melting Point | 137-139°C |
| Solubility | DMSO (120 mg/mL), Acetone (45 mg/mL) |
| Storage | -20°C in amber vials (36 months) |
| Isomer Control | Psoralen ≤0.5% (HPLC-verified) |
Pharmaceuticals
Topical PUVA Gels: 0.01-0.1% w/w for vitiligo clinics
Anticancer Prodrugs: Conjugates with EGFR-targeting peptides
Cosmeceuticals
Nail Fungus Solutions: 5% lacquers with terbinafine (synergy index 2.1)
Hair Regrowth Serums: 0.02% nanoemulsions ↑ anagen phase by 48%
Agriculture
Plant Defense Elicitors: 50 ppm sprays induce phytoalexins in grapes
Postharvest Protection: Reduces Botrytis rot in strawberries by 81%
Isomeric Purity
Angular furanocoumarin structure (5,6-fused ring)
Chromatographic separation: ΔRf 0.17 vs. psoralen
Green Crystallization
Ethyl lactate solvent system (non-toxic, biodegradable)
Yield: 94.5% with crystal size 50-100 μm
Global Compliance
DMF filed: US DMF #035215, CEP 2023-0018
Pharmacopeia: Complies with EP 11.0 monograph
| Quantity | Packaging Method | Shelf Life |
|---|---|---|
| 10g | Amber glass vial + PTFE liner | 36 months |
| 25g | Aluminum foil pouch + zip seal | 36 months |
| 100g | HDPE jar with nitrogen purge | 36 months |
| 500g | Vacuum-sealed steel can | 24 months* |
| 1kg | UN fiber drum + poly liner | 24 months* |
| *Storage at -20°C, O? <0.5% |
Identity Confirmation:
FTIR (KBr): 1715 cm?¹ (C=O), 1620 cm?¹ (C=C)
MS (EI): m/z 186 [M]?
Impurity Profile:
Psoralen <0.5%, Bergapten <0.3%
Stability:
Maintains >95% potency after 24 months at -20°C
Cold Chain Shipping:
≤500g: Dry ice (-78°C)
≥1kg: Refrigerated LTL (2-8°C)
Documentation:
Batch-specific COA with:
• HPLC chromatogram (246 nm)
• Residual solvent analysis (GC-MS)
• Heavy metals report (Pb<0.3 ppm, Cd<0.1 ppm)
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