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High-Purity Micheliolide CAS 68370-47-8 | Natural Sesquiterpene Lactone for Research
Micheliolide (CAS: 68370-47-8) is a natural sesquiterpene lactone extracted from Michelia species. It is a bioactive plant compound widely used in pharmaceutical and biomedical research. With ≥98% purity verified by HPLC, it serves as a reliable reference material for studying inflammatory signaling, oxidative stress, and cellular response mechanisms. Supplied with full COA, HPLC, MS, and NMR data for research use only.
Product Name :
MicheliolideCAS No. :
68370-47-8Appearance :
White to off-white crystalline powderSpecification :
98%Product Name: Micheliolide
Synonyms: (−)-Micheliolide, Guaiacane sesquiterpene lactone, Natural lactone compound
CAS Number: 68370-47-8
Molecular Formula: C15H20O3
Molecular Weight: 248.32 g/mol
Appearance: White to off-white crystalline powder
Source: Extracted from Michelia compressa and Michelia champaca
Category: Natural sesquiterpene lactone / Bioactive phytochemical / Anti-inflammatory compound
Micheliolide (CAS: 68370-47-8) is a naturally occurring sesquiterpene lactone isolated from the Michelia genus (Magnoliaceae family). It is structurally related to parthenolide and guaianolide-type compounds, featuring an α-methylene-γ-lactone moiety known for strong biological reactivity and pharmacological potential.
As a bioactive plant-derived lactone, Micheliolide exhibits a variety of biological activities, including anti-inflammatory, anticancer, immunomodulatory, and neuroprotective effects. Recent studies highlight its promising role as a natural inhibitor of NF-κB and STAT3 pathways, making it a valuable small molecule in inflammation and cancer research.
Micheliolide also serves as a precursor for dimethylaminomicheliolide (DMAMCL) — a stable water-soluble derivative currently under investigation as a potential anticancer drug candidate. Its ability to modulate cellular signaling, induce apoptosis in tumor cells, and suppress inflammatory mediators such as IL-6, TNF-α, and COX-2 underscores its significance in modern biomedical studies.
We provide ≥98% high-purity Micheliolide, supported by complete analytical documentation (COA, HPLC, MS, NMR), ensuring consistency and reliability for scientific research and development.
?? High Purity: ≥98% verified by HPLC – ideal for pharmaceutical and academic research applications
?? Natural Source: Extracted and refined from Michelia plant species
?? Potent Bioactivity: Exhibits anti-inflammatory, anticancer, and immunoregulatory properties
?? Research Grade: Suitable for use in molecular biology, pharmacology, and cell culture studies
?? Full Analytical Support: COA, HPLC chromatograms, MS, and NMR spectra available upon request
Pharmaceutical Research:
Explored for potential use in anticancer, anti-inflammatory, and immunomodulatory therapies.
Signal Pathway Studies:
Used to study NF-κB, STAT3, and ROS-related cellular signaling mechanisms.
Cancer Biology:
Evaluated for induction of apoptosis and suppression of tumor proliferation in various cancer models.
Inflammation & Immune Studies:
Applied in studies involving macrophage activation, cytokine regulation, and inflammatory mediator inhibition.
Drug Development Research:
Serves as a key intermediate in synthesizing dimethylaminomicheliolide (DMAMCL), a promising anticancer lead compound.
| Property | Specification |
|---|---|
| Product Name | Micheliolide |
| CAS Number | 68370-47-8 |
| Molecular Formula | C15H20O3 |
| Molecular Weight | 248.32 g/mol |
| Appearance | White to off-white crystalline powder |
| Purity | ≥98% (HPLC) |
| Source | Michelia compressa / Michelia champaca extract |
| Solubility | Soluble in DMSO, ethanol, and methanol; slightly soluble in water |
| Storage | –20 °C, dry, protected from light |
| Shelf Life | 24 months under proper storage conditions |
Each batch of Micheliolide undergoes rigorous analytical testing to ensure purity, consistency, and structural integrity.
HPLC Purity: ≥98% verified by high-performance liquid chromatography
Structural Confirmation: Validated by Mass Spectrometry (MS) and NMR (¹H & ¹³C)
UV-Vis & IR Characterization: Confirms lactone and guaianolide structural features
Residual Solvent Analysis: Conducted in accordance with ICH Q3C standards
Moisture Content: ≤1.0%, measured by Karl Fischer titration
Heavy Metals: ≤10 ppm (ICP-MS)
Microbial Limits: Free from bacterial and fungal contamination
Each order is accompanied by a Certificate of Analysis (COA), HPLC chromatogram, and MS/NMR spectra for complete data traceability.
? Professional Manufacturer & Supplier – Specializing in natural sesquiterpene lactones and plant-derived bioactives
? High Analytical Purity – Verified by advanced HPLC, MS, and NMR instruments
? Flexible Supply Options – From small-scale research quantities to bulk manufacturing
? Trusted Worldwide – Supplied to pharmaceutical, nutraceutical, and academic research institutions
? Secure Global Shipping – Controlled packaging and temperature stability during delivery
Standard Packaging: 20 mg, 100mg, 100mg, 1g,5g,10g,100g
Bulk Packaging: Available upon request
Custom Options: Tailored packing solutions for specific research or project needs
All shipments are handled under controlled, light-protected, and temperature-stable conditions to maintain product integrity during international transport.
Looking for high-purity Micheliolide (CAS: 68370-47-8) for anti-inflammatory, oxidative stress, or oncology research?
We supply ≥98% research-grade Micheliolide with complete analytical documentation and professional technical support.
?? Website: www.km-origus.com.cn
?? Contact us today for quotations, samples, or detailed technical data sheets.
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