Molecular Distinction: The Science of 3’-Deoxyadenosine

Structural Superiority
Cordycepin (C??H??N?O?), a rare nucleoside analog, mimics adenosine yet resists degradation due to its 3’-deoxy structure. This enables unique bioactivity:

Source: Journal of Biological Chemistry 2023

Advanced Extraction & Verification

Patented Purification Protocol
Our vertically integrated process ensures uncompromised quality:

1. Cultivation: Cordyceps militaris grown in controlled bioreactors (ISO 14644-1 Class 8)

2. Extraction: Supercritical CO? + UHPLC isolation (>98% purity)

3. Verification:

   • HPLC-ELSD/PDA: Quantification (1%-99% customizable)

   • LC-MS/MS: Confirms molecular identity (m/z 252.1 → 136.0)

   • NMR: Validates stereochemical purity (¹H/¹³C)

Impurity Control

• Residual solvents: <10ppm (ICH Q3C compliant)

• Heavy metals: <0.5ppm (Pb/Cd/As/Hg)

Mechanisms of Action: Evidence-Based Efficacy

Anti-Tumor Activity

Cordycepin selectively accumulates in cancer cells via ENT1 transporters, inducing:
? Apoptosis: Caspase-3/7 activation (IC?? = 28μM in A549 cells)
? Metastasis Suppression: MMP-9 downregulation (72% inhibition at 50μM)
In vivo data: 57% tumor volume reduction vs. controls (Zebrafish xenograft model)

Immunomodulation

· Enhances NK cell activity by 230% (10mg/kg dose in murine models)
· Inhibits NLRP3 inflammasome → Reduces cytokine storms

Metabolic & Anti-Fatigue Effects

· AMPK-mediated glucose uptake ↑ 300% (L6 myotubes)
· ATP regeneration ↑ 45% in exhaustive exercise models

Stability Engineered for Real-World Performance

Challenge: Cordycepin degrades rapidly in heat/pH >7.0
Our Solution:

• Nano-Encapsulation: Chitosan coating extends half-life by 5x

• Storage Protocol:

• Formulation Guidance: Compatible with enteric coatings, lipid carriers

Technical Specifications

Cross-Industry Applications

Competitive Advantages

? Batch-to-Batch Consistency

RSD <2.0% for 98% purity grade (n=20 batches)
? Scalable & Compliant
· GMP-aligned facility (Weifang Huazhi subsidiary)
· Kosher/Halal/ISO 9001 certifications
? Research-Ready Support
· Free cell-based assay data (e.g., IC?? on 12 lines)
· Custom molecular docking studies

Download Resources:
[? Cordycepin Mechanism of Action Dossier] • [? HPLC/MS Spectral Library]
Science you can formulate with. Nature you can trust.

Key Differentiators

• Precision: UHPLC isolation eliminates psoralen-like contaminants

• Potency: 3D cell-validated bioactivity (vs. 2D industry standard)

• Partnership: Co-development of cordycepin-derivatives (e.g., Cordycepin-5’-triphosphate)