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20(S)-Protopanaxatriol (PPT) is a high-purity aglycone metabolite derived from ginsenosides, isolated from Panax ginseng roots. As a key reference standard, it enables advanced research in oncology, neuroprotection, and metabolic regulation. With ≥98% HPLC-verified purity and batch-specific CoA, this compound meets pharmacopeial requirements for drug development and quality control.
Product Name :
20(S)-ProtopanaxatriolCAS No. :
34080-08-5Appearance :
White to off-white crystalline powderSpecification :
40%-98%Molecular Formula: C??H??O? | Molecular Weight: 476.73
Appearance: White crystalline powder (colorless needles in methanol) | Melting Point: 261–263°C (20S-isomer)
Source: Roots of Panax ginseng
? Precision-Grade Purity & Multi-Target Bioactivity
Flexible Purity (40%–98%): Rigorously optimized for diverse applications:
≥98% (HPLC-ELSD): For drug development & cellular assays (lot-specific COA with NMR/MS data) 1310
70%–90%: Cost-effective for cosmetics/nutraceutical formulations
40%–60%: Bulk industrial extracts for preliminary screening
Bioactivity Validated: Confirmed dual modulation of glucocorticoid receptor (GR) and estrogen receptor (ERβ), with LXRα inhibition (IC??: 482 nM for Ca²? flux in HUVECs)
? Clinically Relevant Benefits
Neuroprotection: Reduces cerebral infarction area by 58% in MCAO stroke models and alleviates brain edema
Anti-Tumor Adjuvant: Induces dendritic cell maturation for tumor-specific cytotoxicity and suppresses metastasis via integrin β1/FAK pathway
Metabolic Regulation: Inhibits LXRα-driven lipogenesis (↓ SREBP-1c, ↓ triglyceride accumulation in hepatocytes)
| Parameter | Specification |
|---|---|
| Purity Grades | 40%/70%/90%/98% (HPLC-ELSD, custom options) |
| Isomer Ratio | 20(S):20(R) ≥99:1 (Chiral HPLC-C18) 10 |
| Identification | NMR (1H/13C), HRMS, Optical Rotation: +20.5° |
| Solubility | DMSO (50 mg/mL), ethanol; insoluble in water |
| Storage | 2–8°C, sealed under N?, protected from light |
| Shelf Life | 24 months (stability-validated) |
?? Neuropharmacology & Stroke Therapy
Ischemic Stroke Recovery: Improves motor function in MCAO rats by 45% via BDNF/TrkB pathway activation
Anti-Depressant Effects: Modulates hippocampal GABA? receptors (↓ corticosterone by 52% in chronic stress models)
?? Oncology & Immunology
Dendritic Cell Activation: Synergizes with antigens to enhance tumor-specific CTL responses
Chemo-Adjuvant: Reverses P-gp-mediated drug resistance in leukemia (K562/ADR cell line)
?? Cosmetic & Nutraceuticals
Skin Barrier Repair: Upregulates ceramide synthesis for anti-aging formulations (70% purity grade)
Metabolic Health: Controls lipid accumulation in obesity models (LXRα-dependent pathway)
| Advantage | Impact |
|---|---|
| Purity Flexibility | Tailored cost/performance ratios for R&D vs. bulk use |
| Sustainable Sourcing | Traceable to cultivated Panax ginseng (DNA-barcoded) |
| Analytical Rigor | Lot-specific activity reports (GR/ER binding assays included) |
| Global Compliance | ISO 9001/Kosher, heavy metals ≤5 ppm (USP/EP) |
| Purity Grade | Primary Packaging | Quantity Range | Shipping Protocol |
|---|---|---|---|
| ≥98% | Amber glass vials | 20mg–100mg | Dry ice (-78°C), 3–7 days |
| 70%–90% | Pharma-grade PET bottles | 100mg–10kg | Cold chain (2–8°C), 5–10 days |
| 40%–60% | GMP-compliant drums | 10kg–100kg | Sea freight (-20°C monitored), 15–45 days |
Q: How to select purity grade for neuroprotective studies?
→ Free 20mg samples (98% grade) provided with stroke model efficacy data (e.g., MCAO infarction reduction)
Q: Solubility challenges in topical formulations?
→ Solution: Nano-emulsion kits available (OEM service; ↑ water dispersibility 500-fold)
Q: Stability in cell culture media?
→ Stable for 72h in serum-free buffers (recommend fresh DMSO stock ≤10mM)
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