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Hederagenin (CAS 465-99-6) | High-Purity Triterpenoid Standard for Anti-Tumor & Anti-Inflammatory Research
Hederagenin is a naturally occurring triterpenoid saponin extracted from Hedera nepalensis (Ivy family). It exhibits potent anti-inflammatory and anticancer activities by targeting key signaling pathways, making it a critical compound for pharmacological research.
Product Name :
HederageninCAS No. :
465-99-6Appearance :
White crystalline powderSpecification :
98%CAS: 465-99-6
Molecular Formula: C??H??O?
Molecular Weight: 472.7
Appearance: White crystalline powder
Dual-Action Anticancer & Anti-Inflammatory Triterpenoid
≥98% Purity: Pharmaceutical grade (HPLC-ELSD/NMR-verified)
Pro-Apoptotic Trigger: Induces mitochondrial permeability transition in leukemia HL-60 cells via cytochrome c release
Metabolic Synergist: Enhances insulin sensitivity in diabetic models at 50 mg/kg doses
Leukemia Cell Suppression:
Inhibits HL-60 proliferation by 78% at 40 μM via G0/G1 cell cycle arrest and caspase-3 activation.
Selectively targets cancer cells without toxicity to normal hematopoietic stem cells (IC??: 28.3 μM vs. >100 μM in controls).
Anti-Arthritic Activity:
Oral dose of 5 mg/kg/day reduces joint inflammation by 62% in RA models through NF-κB pathway inhibition.
Metabolic Regulation:
Lowers fasting glucose by 18% and improves insulin sensitivity in pre-diabetic models.
Mucosal Barrier Repair:
At 0.5–2.0%, accelerates epithelial healing via COX-2 downregulation (75%) in colitis models.
| Parameter | Detail |
|---|---|
| Purity Range | ≥98% (HPLC-DAD/ELSD, λmax 210 nm) |
| Source | Hedera nepalensis roots |
| Melting Point | 331–334°C 57 |
| Solubility | Water (hot), methanol/ethanol (hot); insoluble in ether |
| Storage | 2–8°C in amber vials (24-month stability) |
| Key Impurities | Oleanolic acid ≤0.5% (HPLC-controlled) |
| Certifications | ISO 9001 |
Oncology Adjuvants:
Synergizes with paclitaxel (10–25 μM) to enhance solid tumor apoptosis in xenograft models.
Metabolic Health Supplements:
50–100 mg doses in nutraceuticals improve glucose uptake and lipid metabolism.
GI Therapeutics:
Dual modulation of intestinal motility—spasmolytic at 0.1 mg/kg, prokinetic at 1 mg/kg.
Topical Anti-Inflammatory Creams:
1–3% formulations accelerate mucosal repair in eczema/colitis.
Eco-Extraction Technology:
Ethanol/water cyclic extraction yields 92% purity with 40% lower solvent residue vs. chloroform methods.
Enhanced Bioavailability:
Phospholipid complexation boosts oral absorption 3.2× (AUC: 42.1 μg·h/mL vs. 13.2 μg·h/mL free form).
Global Compliance:
Full dossiers for FDA IND, EMA Herbal Medicinal Products, and China NMPA registration.
| Cargo Weight | Packaging Method | Shipping | Lead Time | |
|---|---|---|---|---|
| 1–100 mg | Vacuum-sealed glass vials | Dry Ice FedEx | 5 days | |
| 100 mg–1 kg | Pharma-grade aluminum cans | Air freight | 7–12 days | |
| >1 kg | Nitrogen-flushed drums | Sea freight | 30–55 days |
How to validate HL-60 apoptosis induction?
Free in vitro assay report (caspase-3 activity + flow cytometry) included with every batch.
Compatibility with hydrophilic formulations?
Use β-cyclodextrin complex for injectables (solubility ↑5× to 12 mg/mL).
Stability in topical emulsions?
Maintains >95% potency for 18 months in anhydrous bases (pH 5.0–7.0); avoid UV exposure.
Ethical Sourcing:
Hedera nepalensis cultivated via regenerative shade farming in Xinjiang (pesticide-free, blockchain traceability).
Custom Derivatives:
Hederagenin Palmitate: Oil-soluble for transdermal patches
Glycosylated Hederagenin: Enhanced BBB penetration for neuro-oncology R&D
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