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Tangeretin (CAS 481-53-8), a polymethoxyflavone (PMF) exclusively sourced from Citrus reticulata (mandarin orange) and Citrus aurantium (bitter orange) peels , is a high-purity crystalline compound with the molecular formula C??H??O? (MW: 372.37 g/mol).
Product Name :
TangeretinCAS No. :
481-53-8Appearance :
White to off-white crystalline powderSpecification :
98%?? Tangeretin (Citrus Polymethoxyflavone)
CAS No.: 481-53-8
Molecular Formula: C??H??O?
Molecular Weight: 372.37 g/mol
Appearance: White to off-white crystalline powder
Source: Citrus reticulata peel (mandarin orange), Citrus aurantium (bitter orange)
Multi-Target Metabolic Regulator & Neuroprotector
≥98% Purity (HPLC-validated), ensuring batch-to-batch consistency and bioactivity.
Anticancer Activity: Inhibits proliferation of liver cancer SMMC and leukemia HL cells (IC??: 15 μM) with no toxicity to normal immune cells.
Neuroprotection: Suppresses Notch signaling, reducing neuroinflammation and Aβ aggregation—potential for Alzheimer’s therapy.
Antitumor & Immunomodulation
Induces apoptosis in cancer cells via Bax/Bcl-pathway activation and caspase cleavage.
Inhibits histamine release from basophils, alleviating allergic responses6.
Anti-Inflammatory & Smooth Muscle Relaxation
Reduces airway spasms by suppressing smooth muscle hypercontraction.
Antifungal activity against skin pathogens (e.g., Trichophyton mentagrophytes).
Cardiovascular Protection
Lowers thrombosis risk and improves microcirculation.
| Parameter | Specification |
|---|---|
| Melting Point | 153–157°C |
| Density | 1.244 g/cm³ |
| Solubility | DMSO (25 mg/mL), ethanol (soluble); insoluble in water |
| Storage | 2–8°C in airtight, light-resistant containers (stability >24 months) |
| Key Impurities | Residual solvents ≤0.5% (HPLC-monitored) |
| Certifications | ISO 9001 |
1. Pharmaceuticals & Nutraceuticals
Oncology Adjuvants: Synergizes with chemotherapy (e.g., doxorubicin), reducing side effects while enhancing efficacy.
Liver Health Formulations: 10–50 mg/dose in hepatoprotective blends (lowers ALT by 48% in NAFLD models).
2. Cosmeceuticals
Anti-Aging Serums (1–3%): Inhibits MMP-1 (82%) and UV-induced collagen degradation.
3. Functional Foods
Stabilized Beverages: β-cyclodextrin inclusion complexes boost water solubility to 35 mg/mL for clear drinks (shelf-life >18 months).
1. Green Extraction Technology
Supercritical CO? Extraction: Solvent-free, yield ≥96%, energy-efficient (40% less vs. ethanol methods).
2. Polymorph Control
Needle Crystals (β-form): Optimized bioavailability (particle size: 100–300 μm) and bulk density (0.45 g/cm³) for tablet compression.
3. Global Compliance
Dossiers prepared for ISO9001 registrations; heavy metals controlled (As <0.1 ppm, Pb <0.2 ppm; ICP-MS).
| Quantity | Packaging Method | Shelf Life |
|---|---|---|
| 100 mg–1 g | Double aluminum foil bag + desiccant | 24 months |
| 1–100g | Pharma-grade HDPE drum + vacuum seal | 24 months* |
| 500g-1 kg | Pharma-grade HDPE drum + vacuum seal | 24 months* |
| *At 2–8°C, RH <40%; ICH Q1A(R2) stability-validated |
Acute Toxicity: LD?? (oral, rat) >1,000 mg/kg; non-genotoxic (OECD 471 compliant).
Handling: Use PPE (gloves, goggles); avoid dust inhalation.
Q1: How to confirm antitumor activity in batches?
→ Batch-specific cytotoxicity reports (e.g., HL-60 cell inhibition) included.
Q2: Solubility for topical formulations?
→ Use PEG-400 as carrier (solubility ↑ to 50 mg/mL).
Q3: Stability in high-pH products?
→ Stable at pH 3–7; add 0.1% ascorbyl palmitate for alkaline formulations.
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