English
What Are You Looking For?
High-Purity Triptolide 98% | CAS 38748-32-2 | Sourced from Tripterygium wilfordii
Triptolide 98% (CAS: 38748-32-2) is a bioactive diterpenoid epoxide derived from the roots and stems of the medicinal plant Tripterygium wilfordii (Thunder God Vine). This high-purity compound is a potent inhibitor of NF-κB activation, making it invaluable for pharmaceutical research, oncology studies, and anti-inflammatory drug development.
Product Name :
TriptolideCAS No. :
38748-32-2Appearance :
White crystalline powderSpecification :
98%Plant Source: Tripterygium wilfordii Hook. f. (Thunder God Vine)
Molecular Formula: C??H??O? | Molecular Weight: 360.4 g/mol
Purity: ≥98% (HPLC-validated)
Appearance: White crystalline powder
| Property | Value |
|---|---|
| Melting Point | 226-227°C |
| Boiling Point | 601.7±55.0°C (760 mmHg) |
| Density | 1.48±0.1 g/cm³ 24 |
| Solubility | Soluble in DMSO (33 mg/mL), methanol, chloroform; insoluble in water |
| Storage | 2-8°C, sealed, dry, and protected from light |
CAS No.: 38748-32-2
Synonyms: PG490, Tripdiolide, Triptolide
Purity: ≥98% (HPLC, UV detection at 215-218 nm)
Packaging: 5 mg, 20 mg, 50 mg, 100 mg, 500 mg, 1 g (customizable)
Stability: Stable under recommended storage; avoid repeated freeze-thaw cycles
Anti-Cancer Activity:
Induces apoptosis in tumor cells by inhibiting c-IAP2/XIAP and enhancing TNF-α-induced cell death.
Targets HSF1-HSP90 complex, suppressing cancer cell proliferation (IC??: 47-73 nM).
Inhibits neuroblastoma colony formation and tumorigenicity in xenograft models.
Anti-Inflammatory & Immunosuppressive Effects:
Blocks NF-κB activation and TGF-β1/Smad signaling, reducing airway smooth muscle proliferation in asthma models.
Synergizes with cyclosporine A to suppress graft-versus-host disease (GVHD) .
Antiviral Action:
Downregulates Epstein-Barr virus (EBV) LMP1 protein, inhibiting B-lymphocyte proliferation.
Osteolysis Inhibition:
Suppresses RANKL-induced osteoclast formation and titanium particle-induced bone resorption in murine models.
Oncology: Potential therapeutic agent for neuroblastoma, leukemia, and solid tumors.
Autoimmune Diseases: Validated for rheumatoid arthritis and asthma via TGF-β/Smad pathway inhibition.
Organ Transplantation: Enhances allogeneic bone marrow transplant survival.
Cell-Based Assays:
Use in DMSO at working concentrations (e.g., 10–100 nM for apoptosis studies).
Centrifuge vials before use to prevent compound adhesion.
Animal Studies:
Dose-dependent suppression of tumor growth (e.g., 0.1–0.3 mg/kg in mice).
Toxicity: High acute toxicity (LD?? in mice: 0.8–0.9 mg/kg, intraperitoneal).
Precautions:
Use personal protective equipment (gloves, N95 mask, eyeshields).
Avoid contact with strong acids/bases 7.
Regulatory: For research use only. Not for human or veterinary drug applications.
Quality Assurance: Batch-specific HPLC/NMR reports available.
Customization: Bulk quantities (>1 g) and formulation support upon request.
Shipping: Dry ice packaging for international delivery.
Cyclopamine 98% (CAS: 4449-51-8), a potent steroidal alkaloid targeting the Hedgehog pathway, selectively inhibits Smoothened (Smo) with IC50 of 46 nM. This pharma-grade inhibitor is validated for oncology research (pancreatic/basal cell carcinoma) and stem cell differentiation studies.
Read More
Ingenol is a high-purity pharmaceutical intermediate derived from natural plant sources. Our product guarantees over 99.0% purity and rigorous quality control, ensuring reliability for research and production needs . With competitive pricing and flexible global logistics, we provide seamless supply chain support to meet diverse customer demands.
Read More
A naturally derived pentacyclic triterpenoid, Lupeol is extracted from plant sources such as strawberries, mangoes, and traditional herbs. With over 99% HPLC purity, our Lupeol meets rigorous pharmaceutical standards for research and production.
Read More
Curculigoside is a high-purity phenolic glycoside isolated from Curculigo species, extensively utilized in pharmacological research for its potent bioactivities. With HPLC-confirmed purity ≥98%, this compound serves as a critical reference standard in drug discovery and mechanistic studies.
Read More
Phorbol 12-Myristate 13-Acetate (PMA) 98% (CAS:16561-29-8) is an ultra-pure, crystalline PKC activator derived from Croton tiglium seeds, validated for tumor promotion and immunology research. With ≥98% HPLC-verified purity, it reliably induces PKC-dependent pathways at 1-100 nM concentrations in models ranging from DMBA-initiated carcinogenesis to neutrophil NETosis studies.
Read More
IPv6 network supported