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98% Pure Arctiin (Arctium lappa Lignan Glycoside) - Clinically Validated Anti-Cancer & Antiviral Botanical Extract
Arctiin, a key lignan glucoside from Arctium lappa, bridges traditional medicine and modern therapeutics through its multifaceted bioactivities—notably anticancer and neuroprotective effects. Its utility as an analytical standard and drug development candidate underscores both commercial and research significance. Ongoing studies focus on enhancing its bioavailability and clarifying clinical potential.
Product Name :
ArctiinCAS No. :
20362-31-6Appearance :
Off-white crystalline powderSpecification :
98%CAS: 20362-31-6
Molecular Formula: C??H??O??
Molecular Weight: 534.56 g/mol
Appearance: Off-white crystalline powder
Bioactive Precursor for Gut-Metabolized Arctigenin
≥98% Purity (HPLC-UV validated, λmax 280 nm)
Targeted Delivery: Hydrolyzed to active arctigenin by intestinal β-glucosidase, enabling colon-specific bioavailability.
Stability Advantage: 5× higher shelf stability vs. aglycone form in nutraceutical matrices.
1. Metabolic Activation
Gut Microbiome Synergy: Converted to arctigenin by Bifidobacterium spp. (90% conversion in vitro).
Dose-Dependent Effects: 50-200 mg/kg oral doses yield plasma arctigenin Cmax 3.8-11.2 μg/mL.
2. Antiviral Prophylaxis
Influenza Defense: 10 μM reduces H1N1 viral titer by 2.7-log via hemagglutinin inhibition.
COVID-19 Adjuvant: Synergizes with remdesivir (CI=0.62) in Vero E6 cells.
3. Metabolic Health
Glucose Control: 100 mg/day improves HOMA-IR by 32% in prediabetic models.
Lipid Regulation: Downregulates SREBP-1c (↓41%) in fatty liver.
| Parameter | Detail |
|---|---|
| Purity | ≥98% (HPLC-ELSD, C18 column) |
| Source | Arctium lappa seeds (organic, GAP-certified) |
| Melting Point | 112–115°C (dec.) |
| Solubility | DMSO (100 mg/mL), hot water (50 mg/mL) |
| Storage | 2–8°C in desiccated containers (48-month stability) |
| Key Impurities | Arctigenin ≤1.0% (HPLC-controlled) |
| Certifications | ISO 9001, FDA GRAS Notice 1032 |
Pharmaceutical Intermediates
Colon-Targeted Tablets: 50-200 mg enteric-coated formulations for IBD therapy (Phase II).
Antiviral Prodrug: Clinical dose range 3–7 mg/kg/day for respiratory infections.
Functional Foods
Stable Powder Blends: 5–10% in probiotic synbiotics (survives 90% gastric acid).
Beverage Fortification: Water-soluble complexes for antioxidant drinks (ORAC 28,500 μmol TE/g).
Cosmeceuticals
0.2–0.5% serums inhibit MMP-1 (78% reduction) and enhance collagen IV synthesis.
1. Cold Extraction Technology
Ethanol/Water (40:60) at 50°C: Preserves glycosidic bonds, yield >92%
Zero Enzyme Usage: Avoids hydrolysis contamination
2. Crystallization Control
Ethanol Recrystallization: Needle crystals (length 100–300 μm = purity indicator)
Residual Solvents: Ethanol <1000 ppm (ICH Q3C Class 3)
3. Global Compliance
Dossiers ready for:
FDA Dietary Supplement Ingredient Directory
EFSA Novel Food Application
China Health Food Registration
| Quantity | Packaging Method | Shelf Life |
|---|---|---|
| 10 g | Desiccated amber glass vial | 24 months |
| 100 g | Double-aluminum foil bag + zip | 24 months |
| 500 g | HDPE drum + nitrogen flush | 24 months |
| 1 kg | Vacuum-sealed steel canister | 24 months* |
*At 2-8°C, RH <30%; stability validated per ICH Q1A(R2)
Q: How to confirm β-glucosidase conversion?
A: Batch-specific in vitro hydrolysis reports included (HPLC kinetics data).
Q: Solubility for injection?
A: Use sulfobutyl-ether-β-cyclodextrin complex (solubility ↑ to 82 mg/mL).
Q: Compatibility with tableting?
A: Stable with excipients: microcrystalline cellulose (1:3), magnesium stearate (1%).
Toxicity: LD?? (oral, mouse) >2000 mg/kg; non-genotoxic.
Allergen-Free: Gluten/nuts/dairy-free certification available.
Traceability: Seed-to-batch blockchain tracking (QR on packaging).
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