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98% Pure Liquiritigenin (CAS 578-86-9) | Natural Flavonoid Standard for Cosmetic & Pharma Research
Liquiritigenin (CAS 578-86-9) is a bioactive dihydroflavone predominantly isolated from Glycyrrhiza uralensis (licorice root). As a key marker compound in traditional Chinese medicine, it demonstrates potent antioxidant, anti-inflammatory, and phytoestrogenic properties.
Product Name :
LiquiritigeninCAS No. :
578-86-9Appearance :
White crystalline powderSpecification :
98%CAS: 578-86-9
Molecular Formula: C??H??O?
Molecular Weight: 256.25
Appearance: White crystalline powder
Selective Estrogen Receptor β (ERβ) Agonist & Anti-Inflammatory Agent
≥98% Purity (HPLC-verified, dual-method COA)
Targeted Bioactivity: Binds ERβ with high affinity (EC?? = 36.5 nM for ERE tk-Luc activation) and suppresses pro-inflammatory mediators (TNF-α, IL-6, COX-2) 25.
Neuro-Protective & Metabolic Benefits: Reduces neuroinflammation and enhances insulin sensitivity in preclinical models 36.
Hormonal Balance & Breast Safety:
ERβ-Selective Action: Activates ERβ without stimulating uterine growth or breast cancer tumorigenesis (MCF-7 xenograft models) 25.
Osteoprotective: Prevents osteoblast apoptosis by inhibiting ROS and TNF-α in MC3T3-E1 cells 5.
Anti-Neuroinflammatory Effects:
Hippocampal Protection: Reduces IL-6, IL-1β, and TNF-α in serum and hippocampus by 40–60% in vivo, mitigating cognitive decline 56.
Antidiabetic Activity:
Glucose Regulation: Derivative Compound 10 (LTG-based) lowers blood glucose by 28% in diabetic models, outperforming isoliquiritigenin analogues 3.
Skin Barrier Repair:
Anti-Redness & Ceramide Boost: At 0.5–2.0%, accelerates eczema recovery via COX-2 inhibition (75%) and ceramide synthesis upregulation 6.
| Parameter | Detail |
|---|---|
| Purity Range | ≥98% (HPLC-DAD, λmax 280 nm) |
| Source | Glycyrrhiza glabra rhizomes (Xinjiang, GACP-certified) |
| Melting Point | 206–208°C |
| Solubility | DMSO, ethanol; insoluble in water |
| Storage | -20°C in amber vials (24-month stability) |
| Key Impurities | Isoliquiritigenin ≤0.5% (HPLC-controlled) |
| Certifications | ISO 9001, REACH, Halal |
Menopausal Health Supplements:
Synergizes with phytoestrogens at 50–100 mg doses to alleviate hot flashes without uterine stimulation 25.
Neuroprotective Formulations:
In creams (1–3%) or nutraceuticals, combats hippocampal inflammation and oxidative stress 6.
Anti-Acne Serums:
At 0.5%, inhibits C. acnes-induced TLR2 activation and normalizes sebum (28% reduction) 6.
Chromatographic Precision:
Purified via high-speed counter-current chromatography (HSCCC), ensuring >98% purity and batch consistency 8.
Enhanced Bioavailability:
Cyclodextrin complexation boosts water solubility by 8× for toners and oral solutions 8.
Global Compliance:
Full dossiers for FDA GRAS, EU Cosmetic Regulation 1223/2009, and China IECIC.
| Cargo Weight | Packaging Method | Shipping | Lead Time |
|---|---|---|---|
| 1–10 g | Vacuum-sealed glass vials | Dry Ice FedEx | 5 days |
| 10–100 g | Pharma-grade aluminum cans | Air freight | 7–12 days |
| >100 g | Nitrogen-flushed drums | Sea freight | 30–55 days |
How to verify ERβ agonist activity?
Free in vitro assay report (ERE tk-Luc activation) with every batch.
Compatible with retinoids?
Yes—stabilizes retinol in pH 5.0–6.5 serums and enhances collagen synthesis.
Stability in creams?
Maintains >90% potency for 18 months in anhydrous bases.
Traceable Botanicals:
Glycyrrhiza glabra from regenerative farms in Xinjiang (pesticide-free, soil-to-vial blockchain tracking).
Custom Derivatives:
Liquiritigenin Acetate (enhanced blood-brain barrier penetration) for neurological R&D.
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